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Where are stem
cells used
Where are stem cells used
Umbilical cord blood was successfully used for the first time in 1988 in France. Since then umbilical cord blood was used over 60 000 times for therapies in hospitals around the world. Samples from Stemlab were released for the first time in 2007.
Currently stem cells from the cord blood are used in medicine as a standard therapy in 80 diseases, there are also clinical trials that use cord blood for both stem cell transplants and emerging therapies in regenerative medicine. See the list of diseases published and revised by EBMT - European Society for Blood and Marrow Transplantion.
List of medical conditions treated with stem cells
Acute leukaemias
- acute lymphoblastic leukaemia (ALL)
- acute myeloid leukaemia (AML)
- acute biphenotipic leukaemia
- poorly differentiated acute leukaemia
Chronic leukaemias
- chronic myeloid leukaemia (CML)
- chronic lymphocytic leukaemia (CLL)
- juvenile chronic myeloid leukaemia (JCML)
- juvenile myelomonocytic leukaemia (Naegeleg leukaemia) (JMML)
Myelodisplastic syndrome
- refractory anaemia (RA)
- refractory anaemia with ringed sideroblasts (RARS)
- refractory anaemia with excess blasts (RAEB)
- refractory anaemia with excess blasts in transformation (RAEB-T)
- chronic myelomonocytic leukaemia (CMML)
Diseases caused by stem cell defect
- aplastic anaemia(severe)
- Fanconi anaemia
- paroxysmal nocturnal haemoglobinuria
Myeloproliferative syndromes
- acute myelofibrosis
- myelofibrosis
- polycythaemia vera
- Essentials thromb ocythemia
Hyperplastic disorders of lymphatic system
- non-Hodgkin lymphoma
- acute lymphogranuloma
- prolimphocytic leukaemia
Phagocytic disorders
- Chediak-Higashi syndrome
- chronic granulomatous disease (CGD)
- neutrophil actin dysfunction
- reticular dysgenesis
Disorders caused by the absence or malfunctioning of enzymes
- mucopolysaccharidoses (MPS)
- Scheie syndrome (MPS-IS)
- Hunter syndrome(MPS-II)
- Sanfilippo syndrome (MPS-III)
- Morquio syndrome (MPS-IV)
- Maroteaux-Lamy syndrome (MPS-VI)
- Sly syndrome, beta- glucoronidase deficiency (MPS-VII)
- adrenoleukodystrophy
- mucolipidosis II
- Krabbe disease
- Gaucher disease
- Niemann-Pick disease
- Wolman disease
- metachromatic leukodystrophy
Histiocytic disorders
- familial erythrophagocytic lymphohistiocytosis
- histiocytosis -X
- hemophagocytosis
Inherited red blood cell abnormalities
- beta thalassemia
- pure red cell aplasia
- sickle cell anaemia
Inherited immune system disorders
- telangiectasia
- Kostmann syndrome
- leukocyte adhesion deficiency
- DiGeorge syndrome
- bare lymphocyte syndrome
- Omenn syndrome
- severe combined immunodeficiency (SCID)
- SCID adenosine deaminase deficiency
- SCID T and B lymphocytes negative
- SCID T lymphocytes negative and B lymphocytes positive
- common variable immunodeficiency
- Wiskotta Aldrich syndrome
- X-linked lymphoproliferative disorder
Other inherited conditions
- Lesch-Nyhan syndrome
- cartilage-hair hypoplasia
- Glanzmann’s thrombasthenia
- osteopetrosis (marble bone disease)
Hereditary thrombotic disorders
- mega-karyocytosis (inherited thrombocythemia)
Plasma cell disorders
- multiple myeloma
- plasmocythic leukaemia
- Waldenström’s macroglobulinemia
Other forms of cancer
- breast cancer
- Ewing’s sarcoma
- neuroblastoma (sympathicoblastoma)
- kidney cancer